Summer in the Atlanta suburbs fills calendars with golf outings, morning walks, and evenings outdoors. But knee and hip arthritis can stop that momentum fast. More activity often means more pain and stiffness, leaving many people wondering what comes next. Surgery isn't the only answer. Advanced biologic treatments like PRP and BMAC injections are giving patients a compelling option to manage arthritis symptoms and stay active longer.
Understanding Biologic Injection Therapy
Not every arthritis treatment involves surgery. For patients with symptoms that are not yet severe enough for joint replacement, biologic injections have become an increasingly discussed option in orthopedic care.
Unlike cortisone injections, which temporarily reduce inflammation, or hyaluronic acid injections that improve lubrication within the joint, biologic therapies work with the body’s own healing mechanisms. Their goal is to improve the joint environment and potentially slow symptom progression.
Two commonly discussed biologic treatments are platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC). Because both use material derived from the patient’s own body, they reduce the risk of rejection and appeal to patients seeking minimally invasive treatment options.
PRP Injections: Using the Body’s Natural Healing Factors
Platelet-rich plasma therapy begins with a routine blood draw. The blood is processed in a centrifuge to concentrate platelets, creating a solution that is then injected into the affected joint.
Platelets do more than help blood clot. They also contain growth factors involved in tissue repair and inflammation regulation.
In patients with arthritis, PRP may help reduce pain and improve joint function by supporting the environment around damaged cartilage. Research continues to evolve, and outcomes vary between patients, but many individuals with knee arthritis report symptom improvement.
PRP is often considered for patients with early to moderate osteoarthritis who want to remain active and delay surgery while pursuing non-surgical care.
BMAC: Advancing Regenerative Orthopedic Care
Bone marrow aspirate concentrate builds on the same biologic concept but uses bone marrow instead of blood.
Bone marrow is commonly collected from the pelvis during an office or outpatient procedure. After processing, the concentrated material is injected into the affected joint.
BMAC contains growth factors, anti-inflammatory proteins, and mesenchymal stem cells, which have shown the ability to develop into cartilage and bone tissue under certain conditions.
For patients with more advanced arthritis or those who have not responded sufficiently to PRP, BMAC may be considered as another biologic option.
While interest in BMAC continues to grow, it remains an area of active research. Outcomes depend on multiple factors including the degree of arthritis, activity level, overall health, and joint condition. Careful evaluation remains essential when determining candidacy.
How PRP and BMAC Fit Into Arthritis Care
Biologic injections are typically most effective when included within a broader arthritis management plan rather than used as standalone treatments.
A comprehensive strategy may include:
- Physical therapy
- Weight management
- Activity modification
- Anti-inflammatory medications
- Traditional injections such as cortisone or hyaluronic acid
PRP and BMAC are designed to influence the joint environment rather than directly rebuild damaged cartilage. Their goal is to reduce inflammation, improve function, and help preserve quality of life.
Patients who eventually require joint replacement generally do not compromise future surgery by pursuing conservative treatment first. Maintaining strength and mobility often supports better recovery if surgery becomes necessary later.
Frequently Asked Questions
How many PRP injections are needed for arthritis?
Treatment varies by patient and arthritis severity. Many patients receive one to three injections spaced several weeks apart. Some improve after a single treatment, while others benefit from a series. Recommendations depend on symptoms, imaging findings, and overall joint health.
Is BMAC better than PRP for knee arthritis?
Neither treatment is universally better. PRP is commonly used for early to moderate arthritis and requires only a blood draw. BMAC contains additional cellular components and may be considered in more advanced cases. The best option depends on individual goals and clinical findings.
How long do PRP injections last?
Many patients experience symptom relief lasting six months to one year or longer, although results vary. Arthritis severity, activity level, body weight, and treatment protocols all influence duration. Repeat treatments may be considered if symptoms return.
Are PRP and BMAC covered by insurance?
Most insurance providers currently classify PRP and BMAC as investigational treatments for arthritis, so coverage is often limited. Many practices offer self-pay options and discuss costs during consultation.
Who is a good candidate for biologic injections?
Patients with mild to moderate osteoarthritis who have not found adequate relief from physical therapy, medications, or traditional injections may be candidates. Individuals hoping to delay surgery and maintain activity levels often explore these options.
Biologic injections have expanded treatment possibilities for patients navigating the space between early arthritis and joint replacement. For those in the greater Atlanta area looking to stay active and manage symptoms conservatively, understanding PRP and BMAC may be an important step toward long-term joint health.
Reference Links:
- Case study: Use of platelet-rich plasma and bone marrow aspirate concentrate injections to treat knee osteoarthritis - Mayo Clinic
- Bone Marrow Aspirate Concentrate (BMAC) for Knee Osteoarthritis: A Narrative Review of Clinical Efficacy and Future Directions - PubMed Central
AUTHOR: Richard Boe, M.D., FAAOS – Board-Certified Fellowship-Trained Hip & Knee Specialist
Richard Boe, M.D., FAAOS is a fellowship-trained orthopedic surgeon specializing in adult reconstruction of the hip and knee. He practices with Resurgens Orthopaedics in the Atlanta suburbs, providing comprehensive joint care to patients in Austell, Douglasville, Vinings, and West Cobb, Georgia. Dr. Boe is dedicated to restoring mobility, relieving pain, and delivering patient-centered care through both advanced surgical techniques and thoughtful non-surgical management.
Credentials & Recognition
Dr. Boe completed his Adult Reconstruction Fellowship at the Hospital of the University of Pennsylvania. He finished his Orthopedic Surgery Residency at Marshall University School of Medicine and earned his Doctor of Medicine degree from Virginia Commonwealth University School of Medicine. He also holds a B.S. in Biomedical Engineering from Virginia Commonwealth University, graduating magna cum laude with University Honors.
Dr. Boe is a Fellow of the American Academy of Orthopaedic Surgeons with accolades including the Dr. Russell P. Seneca Award for Excellence in Surgery and multiple academic scholarships. Dr. Boe has presented his research at national meetings and has published on topics such as soft-tissue balancing in total hip arthroplasty and management of persistent wound drainage after joint replacement.
Clinical Expertise
Dr. Boe specializes in advanced hip and knee replacement procedures, utilizing modern surgical techniques to optimize alignment, stability, and long-term function. He also provides comprehensive non-surgical arthritis management to help patients reduce pain and maintain joint health when surgery is not yet necessary. With a background in biomedical engineering and extensive clinical training, Dr. Boe combines technical precision with compassionate care. His approach emphasizes individualized treatment plans designed to achieve faster recovery, improved mobility, and lasting outcomes.
Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice. For diagnosis and treatment recommendations, please consult with Dr. Boe or another qualified orthopedic specialist.